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The Guest Room is one of the rooms within the ThunderCats' fortress, the Cats Lair. This spare bedroom is for any guest whom the ThunderCats invite into the lair. Like the other ThunderCats' Bedrooms, the Guest Room also has a bed, a wardrobe and some small pieces of furniture like drawers and stools.
When Mumm-Ra disguised as Pumm-Ra won over the ThunderCats' trust, they let him sleep in the Guest Room while they deliberated on whether to make him an honorary ThunderCat.
Another time when Mumm-Ra disguised himself as an injured Berbil, he also stayed in the Guest Room.